产品货号：
Z31059
中文名称：
ERBB3抗体
英文名称：
Anti-ERBB3 Antibody (Clone#3F10F6)
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ERBB3 Antibody (Clone#3F10F6) |
| 指标别名 | c erbB 3;c erbB3;ErbB 3;ERBB3;erbB3 S;HER3;LCCS2;MDA BF 1;p180 ErbB3;p45 sErbB3;p85 sErbB3 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | ERBB3 |
| 克隆号 | 3F10F6 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG |
| 免疫原 | Purified recombinant fragment of ErbB-3 (aa1175-1275) expressed in E.Coli. |
| 计算分子量 | 148KD |
| 成分 | Ascitic fluid containing 0.03% sodium azide. |
| 纯化方式 | Affinity purification |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | ERBB3(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) also known as ONCOGENE ERBB3 or HER3,is an enzyme that in humans is encoded by the ERBB3 gene.This gene encodes a member of the epidermal growth factor receptor(EGFR) family of receptor tyrosine kinases.This membrane-bound protein has a neuregulin binding domain but not an active kinase domain.By in situ hybridization,Kraus et al.(1989) mapped the ERBB3 gene to chromosome 12q13.Carraway et al.(1994) demonstrated that ERBB3 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself.Most notably,EGFR and ErbB2 became markedly more promiscuous as the threshold was lowered,whereas ErbB3did not.Engelman et al.(2007) found that amplification of MET caused gefitinib resistance by driving ERBB3-dependent activation of phosphoinositide 3-kinase,a pathway though to be specific to EGFR/ERBB family receptors. |
| Uniprot ID | P21860 |
| 基因名全称 | Receptor tyrosine-protein kinase erbB-3 |
| 蛋白名全称 | Receptor tyrosine-protein kinase erbB-3 |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:200～1:1000 ELISA 1:10000 |
相关搜索：ERBB3抗体，ERBB3单抗，Anti-ERBB3 Antibody (Clone#3F10F6)